Does Niacinamide contribute to diabetes and insulin resistance?

Vitamin B3 comes in a few forms, with niacin (nicotinic acid (NA)), niacinamide (NAM), nicotinamide riboside (NR) and inositol hexanicotinate being the most famous. As you can see from the picture, vitamin B3 can come in three forms from the diet, namely NA, NAM and NR, whereas an endogenous pathway can also synthesize NAM from … Continue reading Does Niacinamide contribute to diabetes and insulin resistance?

Different fats and inflammation

Let me just start off by saying that fat gain happens mostly in the presence of caloric excess (when more calories are consumed than is being burned). For healthy adipose tissue expansion, there needs to be acute inflammation, collagen remodeling and growth of new blood vessels (angiogenesis). Without these factors, healthy fat gain cannot take … Continue reading Different fats and inflammation

Metabolic efficiency is more important than mitochondrial quantity

It has been hypothesized that insulin resistance in patients with impaired, or diabetic glucose tolerance, is mediated by a deficiency of mitochondria in skeletal muscle. But it turns out that it's not necessarily the case. This is because type 2 diabetics and insulin-resistant individuals, with impaired glucose tolerance, have ≈30% less mitochondria and 38% lower mitochondrial … Continue reading Metabolic efficiency is more important than mitochondrial quantity