46 ways to increase DHT (2018 update)

  DHT was always thought to be converted from testosterone, however, recent data suggest that instead, it's converted from Δ-androstenedione by 5α-reductase isoenzyme-1 to 5α-androstanedione, followed by subsequent conversion to DHT via the enzyme 17β-hydroxysteroid B3. The 5α-androstanedione pathway to DHT, therefore, bypasses testosterone entirely (1). Androstenedione → 5α-androstanedione → DHT. Also, "DHT formation from 4-dione (androstenedione) increased gradually and … Continue reading 46 ways to increase DHT (2018 update)

Different fats and inflammation

Let me just start off by saying that fat gain happens mostly in the presence of caloric excess (when more calories are consumed than is being burned). For healthy adipose tissue expansion, there needs to be acute inflammation, collagen remodeling and growth of new blood vessels (angiogenesis). Without these factors, healthy fat gain cannot take … Continue reading Different fats and inflammation

Reactive oxygen species created by fats and their affect on insulin signalling

Does fat make you fat? And if the answer is yes then which type of fat is the guilty one? Fat mass expansion in obesity occurs via adipocyte hyperplasia (increased adipocyte number) and/or adipocyte hypertrophy (increased size of adipocytes). The latter is often associated with adipose dysfunction and inflammation. Increased adipocyte size correlates with serum … Continue reading Reactive oxygen species created by fats and their affect on insulin signalling

57 ways to lower Serotonin, the depressing hormone

Serotonin is always thought of being the happy hormone and that by increasing it has an anti-depressant effect. As a matter of a fact, the majority of anti-depressants is selective serotonin reuptake inhibitors, and more than 90% of the people on anti-depressant medication is on SSRI. Before SSRI became so popular, there were studies done … Continue reading 57 ways to lower Serotonin, the depressing hormone

Ketogenic diet – is it safe? (lipid peroxidation, prostaglandins, inflammation)

Two aspects might be of concern when eating a ketogenic diet... Increase ROS due to more saturated fat consumption and more lipid peroxidation due to more unsaturated fat ingestion.   Let's start with the increase in ROS 1 glucose molecule produces 10 NADH and 2 FADH2 through glycolysis and the TCA cycle. During beta-oxidation, for … Continue reading Ketogenic diet – is it safe? (lipid peroxidation, prostaglandins, inflammation)