Androgens such as testosterone and DHT exert their beneficial action on the tissue by binding to androgen receptors. Testosterone and DHT are both anabolic to muscle and boosts muscle growth. A recent study found that, although androgens are needed for muscle growth, it is the androgen receptors that are essential for hypertrophy. There is a … Continue reading 25 ways to increase androgen receptors and enhance potency (2018 update)
DHT was always thought to be converted from testosterone, however, recent data suggest that instead, it's converted from Δ-androstenedione by 5α-reductase isoenzyme-1 to 5α-androstanedione, followed by subsequent conversion to DHT via the enzyme 17β-hydroxysteroid B3. The 5α-androstanedione pathway to DHT, therefore, bypasses testosterone entirely (1). Androstenedione → 5α-androstanedione → DHT. Also, "DHT formation from 4-dione (androstenedione) increased gradually and … Continue reading 46 ways to increase DHT (2018 update)
Vitamin B3 comes in a few forms, with niacin (nicotinic acid (NA)), niacinamide (NAM), nicotinamide riboside (NR) and inositol hexanicotinate being the most famous. As you can see from the picture, vitamin B3 can come in three forms from the diet, namely NA, NAM and NR, whereas an endogenous pathway can also synthesize NAM from … Continue reading Does Niacinamide contribute to diabetes and insulin resistance?
An association between intracellular fat accumulation and insulin resistance has been found. But an associated is not a cause... The hypothesis was that β-oxidation is too slow and as a result, fats start to accumulate in the cells and this causes insulin resistance, thus the inability to transport glucose into the cell and reduced glucose oxidation. … Continue reading Excessive fat oxidation (β-oxidation) drives diabetes
Uncoupling protein, aka thermogenin, are proteins found in the inner mitochondrial membrane of the cell. Protons generated in the Kreb cycle leave the mitochondria via the electron transport chain, and then re-enter the mitochondria via the ATPase enzyme for the synthesis of ATP. This is called coupled respiration. With uncoupled res piration, protons re-enter the … Continue reading Uncoupling: Secret to Fat loss and Health
Blocking the aromatase is crucial for decreasing estrogen, whether you have high testosterone or not. Lower aromatase activity will leaves more testosterone to bind with androgen receptors to exert its anabolic effect, as well as to be converted to DHT via 5-AR (5 alpha reductase). High Estrogen symptoms include: Pelvic pain Night wakings and sweats (can't … Continue reading Signs / symptoms of high estrogen/aromatase and top 5 supplements to inhibit the aromatase
Serotonin is always thought of being the happy hormone and that by increasing it has an anti-depressant effect. As a matter of a fact, the majority of anti-depressants is selective serotonin reuptake inhibitors, and more than 90% of the people on anti-depressant medication is on SSRI. Before SSRI became so popular, there were studies done … Continue reading 57 ways to lower Serotonin, the depressing hormone
There are various forms of niacin out there, a few are nicotinic acid (NA), nicotinamide/niacinamide (NAM), nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Nicotinic acid has a few side effects, such as flushing, nausea, fainting and can even cause insulin resistance and liver toxicity and exacerbate peptic ulcer disease, which NAM doesn't have. (1, 2) B3 … Continue reading 7 amazing benefits of Niacinamide. #4 is boosting brain capacity