Polyunsaturated fats, cardiolipin and ATP production

From the previous article: "the rate of substrate oxidation in resting muscle is not determined/limited by mitochondrial oxidative capacity, but by the rate of ATP breakdown/ADP formation, which is regulated by the cells' need for energy" The mitochondria can only make ATP if there is ADP and a phosphate present. The complex V in the … Continue reading Polyunsaturated fats, cardiolipin and ATP production

Metabolic efficiency is more important than mitochondrial quantity

It has been hypothesized that insulin resistance in patients with impaired, or diabetic glucose tolerance, is mediated by a deficiency of mitochondria in skeletal muscle. But it turns out that it's not necessarily the case. This is because type 2 diabetics and insulin-resistant individuals, with impaired glucose tolerance, have ≈30% less mitochondria and 38% lower mitochondrial … Continue reading Metabolic efficiency is more important than mitochondrial quantity

PUFA Dangers Part 1: storage, mobilization and oxidation

Polyunsaturated fatty acids (PUFAs) are fatty acids which have more than 1 double bond in their structure, whereas saturated fats have no double bonds (only single bonds). The more double bonds a fatty acid has, the more fluid it is, and the longer the saturated fatty acid chain is, the more solid it is. For … Continue reading PUFA Dangers Part 1: storage, mobilization and oxidation