Different fats and inflammation

Let me just start off by saying that fat gain happens mostly in the presence of caloric excess (when more calories are consumed than is being burned). For healthy adipose tissue expansion, there needs to be acute inflammation, collagen remodeling and growth of new blood vessels (angiogenesis). Without these factors, healthy fat gain cannot take … Continue reading Different fats and inflammation

Reactive oxygen species created by fats and their affect on insulin signalling

Does fat make you fat? And if the answer is yes then which type of fat is the guilty one? Fat mass expansion in obesity occurs via adipocyte hyperplasia (increased adipocyte number) and/or adipocyte hypertrophy (increased size of adipocytes). The latter is often associated with adipose dysfunction and inflammation. Increased adipocyte size correlates with serum … Continue reading Reactive oxygen species created by fats and their affect on insulin signalling

Excessive fat oxidation (β-oxidation) drives diabetes

An association between intracellular fat accumulation and insulin resistance has been found. But an association is not a cause... The hypothesis was that β-oxidation is too slow and as a result, fats start to accumulate in the cells and this causes insulin resistance, thus the inability to transport glucose into the cell and reduce glucose … Continue reading Excessive fat oxidation (β-oxidation) drives diabetes

Metabolic efficiency is more important than mitochondrial quantity

It has been hypothesized that insulin resistance in patients with impaired, or diabetic glucose tolerance, is mediated by a deficiency of mitochondria in skeletal muscle. But it turns out that it's not necessarily the case. This is because type 2 diabetics and insulin-resistant individuals, with impaired glucose tolerance, have ≈30% less mitochondria and 38% lower mitochondrial … Continue reading Metabolic efficiency is more important than mitochondrial quantity

Uncoupling: Secret to Fat loss and Health

Uncoupling protein, aka thermogenin, are proteins found in the inner mitochondrial membrane of the cell. Protons generated in the Kreb cycle leave the mitochondria via the electron transport chain, and then re-enter the mitochondria via the ATPase enzyme for the synthesis of ATP. This is called coupled respiration. With uncoupled respiration, protons re-enter the mitochondria … Continue reading Uncoupling: Secret to Fat loss and Health

Macro-nutrients: 3 types of foods you should be eating for testosterone

Eating the correct macro nutrients is a must do if you want to optimize your androgen hormones and your physique... It's a terrible idea to omit any kind of macro nutrient for any kind of goal you might have. Let's get to the meat and potatoes of this post... Protein Protein is actually more important for … Continue reading Macro-nutrients: 3 types of foods you should be eating for testosterone